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Abstract Number 738: Engaging Innate Immunity By AFM28, an Innate Cell Engager (ICE®) Targeting CD123-Positive Leukemic Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia: Safety and Efficacy Results of a First-in-Human Phase 1 Study

Abstract Number 738: Engaging Innate Immunity By AFM28, an Innate Cell Engager (ICE®) Targeting CD123-Positive Leukemic Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia: Safety and Efficacy Results of a First-in-Human Phase 1 Study

BackgroundAFM28 is a high-affinity bispecific CD123/CD16A ICE®, developed for treatment of CD123-expressing hematological malignancies, e.g. acute myeloid leukemia (AML). Its primary mechanism of action is the induction of antibody-dependent cellular cytotoxicity by...
Abstract Number 738: Engaging Innate Immunity By AFM28, an Innate Cell Engager (ICE®) Targeting CD123-Positive Leukemic Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia: Safety and Efficacy Results of a First-in-Human Phase 1 Study

Abstract Number 736: Efficacy and Safety of Pembrolizumab Added to Azacitidine Plus Venetoclax for Patients with Acute Myeloid Leukemia: Results from an Investigator-Initiated, Multi-Center, CTEP-Sponsored Randomized, Phase II Trial (BLAST AML-2)

AMZ, RMS Contributed equally and serve as co-senior authorsBackgroundAZA + VEN is a standard of care treatment for pts with AML who are unfit for intensive chemotherapy. However, long-term survival remains limited. Addition of anti-PD-1 antibody to AZA+VEN may...
Abstract Number 738: Engaging Innate Immunity By AFM28, an Innate Cell Engager (ICE®) Targeting CD123-Positive Leukemic Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia: Safety and Efficacy Results of a First-in-Human Phase 1 Study

Abstract Number 735: Phase 1b/2 Study of Magrolimab (Magro), Azacitidine (AZA) and Venetoclax (VEN) in Patients (pts) with Newly Diagnosed (ND) Older/Unfit or High Risk Acute Myeloid Leukemia (AML) and Relapsed Refractory (R/R) AML: Final Clinical Data and Genomic Markers of Resistance/Relapse

Introduction: Induction therapy with AZA-VEN has become the standard of care for older/unfit pts with ND AML. However, outcomes of AML pts with adverse risk (AR) genomics, and post relapse after AZA-VEN based therapy remain dismal warranting evaluation of novel...