Background: Patients with high-risk AML and MDS have a very poor outcome even with stem cell transplantation (SCT) and need an alternative approach. Busulfan-based conditioning regimens are efficacious in SCT, though relapse remains a major concern. Interestingly,...
Introduction: Patients with NPM1-mutated (NPM1m) acute myeloid leukemia (AML) in the absence of a FLT3-internal tandem duplication (ITD) mutation are considered to have favorable risk disease that may be cured with intensive chemotherapy (IC) alone. Yet as patients...
Introduction: Acute myeloid leukemia (AML) has been considered by many to be an oncologic emergency often leading to hospital admission for expeditious evaluation and treatment. Previous studies reported that time from diagnosis to treatment (TDT) does not impact...
Introduction
TP53 mutations in AML are present in 30% of R/R AML patients and are associated with poor prognosis and resistance to therapy. Earlier experiments have revealed markers of immune dysfunction in the bone marrow microenvironment of TP53m AML. However, what the role of...
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