Venetoclax (VEN) combined with low-dose cytarabine (LDAC) is highly effective in acute myeloid leukemia (AML) with either measurable residual disease (MRD) or oligoblastic (5-15% blasts) relapse (VALDAC study) (Tiong et al, JCO 2024). We have previously shown that...
Acute myeloid leukemia (AML) is a highly aggressive and deadly blood cancer with less than 30% five-year survival. AML develops when hematopoietic stem cells (HSC) or hematopoietic stem and progenitor cells (HSPC) acquire key mutations resulting in leukemic stem cell...
Despite extensive efforts aimed toward the development of improved molecular therapies targeting acute myeloid leukemia (AML), clinical outcomes remain poor. Notably, targeting BCL2 with venetoclax (Ven) in combination with azacitidine (Aza) has clinically delivered...
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