BackgroundAFM28 is a high-affinity bispecific CD123/CD16A ICE®, developed for treatment of CD123-expressing hematological malignancies, e.g. acute myeloid leukemia (AML). Its primary mechanism of action is the induction of antibody-dependent cellular cytotoxicity by...
AMZ, RMS Contributed equally and serve as co-senior authorsBackgroundAZA + VEN is a standard of care treatment for pts with AML who are unfit for intensive chemotherapy. However, long-term survival remains limited. Addition of anti-PD-1 antibody to AZA+VEN may...
Introduction: Induction therapy with AZA-VEN has become the standard of care for older/unfit pts with ND AML. However, outcomes of AML pts with adverse risk (AR) genomics, and post relapse after AZA-VEN based therapy remain dismal warranting evaluation of novel...
IntroductionThe combination of the BCL2 inhibitor venetoclax with intensive chemotherapy with cladribine, idarubicin, and cytarabine (CLIA) has been shown to be safe and effective in younger, fit patients with newly diagnosed acute myeloid leukemia (AML) and high-risk...
Clinical resistance shortens survival for acute myeloid leukemia (AML) patients treated with targeted inhibitors. Resistance mechanisms to AML targeted therapies, including inhibitors of FLT3, BCL2 and IDH1/2, often converge upon the RAS/MAPK signaling pathway....
BackgroundAcute myeloid leukemia (AML) is a heterogeneous disease and is primarily defined by genetic abnormalities. Although accumulating evidence suggests the role of epigenetics in the pathogenesis of AML, it has not fully been investigated in a large cohort of...
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