Aneuploidy is common in solid tumors but only comprises ~10% of acute myeloid leukemias (AML), defined by complex karyotype (AML-CK) and associated with TP53 mutations and 5q loss. The drivers and trajectories of AML-CK evolution have not been experimentally...
Cofactors, many of which are vitamin-derived, are organic molecules with diverse biological functions. They are required for many metabolic pathways and enzymatic reactions, and thus can influence cell proliferation and differentiation. Though the role of vitamins in...
BackgroundIn 2022, the European LeukemiaNet (ELN) updated its guidelines for risk allocation in acute myeloid leukemia (AML) patients (Döhner H et al., Blood 2022). Subsequently, a few studies validated externally the prognostic value of this new classification in...
Background: Patients with high-risk AML and MDS have a very poor outcome even with stem cell transplantation (SCT) and need an alternative approach. Busulfan-based conditioning regimens are efficacious in SCT, though relapse remains a major concern. Interestingly,...
Introduction: Patients with NPM1-mutated (NPM1m) acute myeloid leukemia (AML) in the absence of a FLT3-internal tandem duplication (ITD) mutation are considered to have favorable risk disease that may be cured with intensive chemotherapy (IC) alone. Yet as patients...
Introduction: Acute myeloid leukemia (AML) has been considered by many to be an oncologic emergency often leading to hospital admission for expeditious evaluation and treatment. Previous studies reported that time from diagnosis to treatment (TDT) does not impact...
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